Researchers at Imperial College London’s UK Dementia Research Institute have conducted a study which suggests that being active might be more effective at helping the brain clear toxins than sleeping. Published in Nature Neuroscience, this research, conducted on mice, challenges the long-held belief that sleep is primarily responsible for this detoxification process.

The study reveals that while mice were sleep or under anaesthesia, there was a significant reduction in the brain’s ability to flush out toxins—30% less efficient in sleeping mice and 50% less in those under anaesthesia. The implications of these findings suggest a potential reevaluation of the role of sleep in brain health, particularly in relation to the prevention of conditions such as dementia.

Professors Bill Wisden and Nick Franks, who co-led the study, expressed surprise at these results, highlighting that these findings challenge the conventional view that sleep is essential for clearing brain toxins. They are now looking to confirm whether the same applies to humans.

This research not only questions the function of sleep but also underscores the importance of physical activity in maintaining brain health. The study could lead to further investigation into how different states of consciousness affect the ability to maintain cognitive health, particularly in the context of diseases like Alzheimer’s. Despite these surprising findings, the researchers emphasized that the overall importance of sleep should not be undermined. Further research will explore the complex relationships between sleep, activity, and brain function.