Researchers from UCL and the University of Cambridge have unlocked a potential early indicator for Alzheimer’s disease through the impairment of spatial navigation, presenting an opportunity for earlier diagnosis and intervention.
Researchers from UCL, in collaboration with the University of Cambridge, have found that poor spatial navigation skills could potentially predict Alzheimer’s disease years before the onset of more noticeable symptoms such as memory loss. This discovery came through a study using virtual reality technology to test adults aged between 43 to 66. The study revealed that individuals at risk of Alzheimer’s exhibited impaired spatial navigation capabilities without showing deficiencies in other cognitive functions. Notably, this navigation impairment was more prevalent in men than in women, indicating a potential early marker for Alzheimer’s disease that could manifest decades prior to other symptoms.
The research, published in Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association, received funding from the Alzheimer’s Society and an MSD research grant. It aims to develop diagnostic support tools for the NHS, focusing on early and accurate diagnosis to facilitate timely access to support and treatment. Dr. Coco Newton, the lead author, emphasized the significance of identifying changes in navigation behavior as an early indicator of Alzheimer’s. Dr. Richard Oakley from the Alzheimer’s Society highlighted the potential of this discovery in improving life quality for those affected by dementia through early detection and intervention.
In a parallel study conducted by the University of Toronto, researchers identified that a decline in speaking speed might also serve as an indicator of brain health, particularly regarding the risk of dementia. This study, which examined 125 volunteers across various age groups, suggests that speech speed is a significant factor in assessing cognitive decline, potentially surpassing the relevance of word-finding difficulties traditionally linked with aging. Dr. Jed Meltzer, a co-author, suggested the incorporation of speaking speed into standard cognitive assessments, underlining the necessity of further research in this area for early detection and support of brain health in older adults.
These findings contribute significantly to the field of dementia research, suggesting new avenues for the development of diagnostic tools and interventions that could benefit individuals at risk of cognitive decline and Alzheimer’s disease.
